ABSTRACT
To study therapeutic effects of irbesartan combined amiodarone on heart failure (HF) patients with atrial fibrillation (AF) and its influence on cardiac function ,plasma levels of Ang‐Ⅱ,NE and BNP .Methods :A total of 98 HF patients with AF treated in our hospital from Sep 2016 to Sep 2017 were randomly divided into ami‐odarone group (received amiodarone based on routine treatment ) and combined treatment group (received irbesar‐ tan based on amiodarone group).Both group were treated for six months .HR ,BP ,cardiac function indexes ,plas‐ma levels of Ang‐Ⅱ,NE and BNP before and after treatment ,and incidence of adverse reactions were observed and compared between two groups .Results : Compared with before treatment ,after treatment ,there were significant reductions in HR ,BP ,LVEDd ,LVESd ,plasma levels of Ang‐Ⅱ,NE and BNP ,and significant rise in LVEF in two groups , P＜0. 05 or ＜0. 01. Compared with amiodarone group ,after treatment ,there were significant reduc‐tions in HR [(95. 6 ± 13.7) beats／min vs .(81. 4 ± 11. 8) beats／min] ,BP [(145. 7 ± 20.6)／(89.1 ± 11.4) mmHg vs.(132.3 ± 17.5)／(81.3 ± 10.2) mmHg] ,LVEDd [ (58.3 ± 5.2) mm vs.(53.2 ± 4.6) mm] ,LVESd [ (44. 2 ± 5. 1) mm vs.(38.1 ± 4.9) mm] ,plasma levels of Ang‐Ⅱ[(113.27 ± 10.14) pg／ml vs.(98.67 ± 8. 79) pg／ml] , NE [(1.90 ± 0. 31) pg／ml vs.(1.74 ± 0. 28) pg／ml] and BNP [(282.18 ± 54.16) pg／ml vs.(214. 36 ± 41. 25) pg／ml] ,and significant rise in LVEF [(39.8 ± 4.1)% vs.(48.6 ± 5. 5)%] in irbesartan group ,P＜0.01 all.There was no significant difference in incidence rate of adverse reactions during treatment between two groups , P＝ 0.712. Conclusion :Irbesartan combined amiodarone can effectively improve cardiac function ,reduce HR ,BP ,plasma lev‐els of Ang‐Ⅱ,NE and BNP with good safety in HF patients with AF .
ABSTRACT
Objective To observe clinical efficacy of atorvastatin combined with clopidogrel for treatment of patients with unstable angina and its influences on hypersensitive C-reactive protein (hs-CRP) and prognosis of such patients. Methods Data of four hundred and thirty patients with unstable angina pectoris admitted to Tangshan Worker's Hospital from January 2013 to December 2017 were collected, and according to difference in drug application, they were divided into control group and observation group, with 215 patients in each group. Both groups were treated with routine western therapy; the patients in the control group were subjected to enteric-coated aspirin (the initial dose was 300 mg and the maintenance dose 100 mg/d) atorvastatin therapy (20 mg orally taken, once a day) on the basis of conventional therapy, subcutaneous injection of 4.1 kU low molecular weight heparin calcium every 12 hours once time for 7 days; the patients in the observation group were subjected toatorvastatin therapy (similar dosage used in the control group) and clopidogrel therapy (the initial dose was 30 mg and the maintenance dose was 75 mg/d) on the basis of conventional treatment. After both groups were treated for 6 months, their clinical efficacies were evaluated. The differences of cholesterol (TC), triacylglycerol (TG), hs-CRP were compared before and after treatment between the two groups, and the clinical curative effect, and drug adverse reaction were observed in the two groups. Results After treatment, the total effective rate of the observation group was significantly higher than that of the control group [92.56% (199/215) vs. 73.48% (158/215), P < 0.05, P < 0.05]. After treatment, the levels of TC, TG and hs-CRP in the two groups were lower than those before treatment, and the above indexes in the observation group were significantly lower than those in the control group [TC (mmol/L): 2.28±0.29 vs. 3.81±1.33, TG (mmol/L): 4.35±0.32 vs. 7.77±0.24, hs-CRP (mg/L): 5.41±2.26 vs. 7.15±3.22, all P < 0.05].There was no significant difference in the incidence of adverse reactions between the observation group and the control group [7.91% (17/215) vs. 10.25% (22/215), P > 0.05]. Conclusion Atorvastatin combined with clopidogrel for treatment of unstable angina pectoris can effectively lower the level of hs-CRP,and it has important significance for improving the prognosis of such patients.
ABSTRACT
Objective To make a survey of the binocular visual acuity, residual visual acuity and the pathogenic factors causing the deficient of the vision handicap student in Blindness-Deaf-Mute school in Guiyang to provide the data for low vision rehabilitation. Methods Through routine examination, we examined the 58 students with vision impairment and further advised them wear the optics visual aids. Results 6 cases of low vision, accounting for 10.3%; 52 cases of blindness, accounting for 89.7%. One case was rectified its visual acuity by means of subjective refraction and rectification of eyesight. Causes of the disease: 35 cases suffered from the deficient due to genetic factors, accounting for 60.3%; among them, the congenital glaucoma was the first (12/35). 23 cases suffered from the deficient due to acquired factors, accounting for 39.7%, among them, the keratomalacia was the first (19/23). Visual aids wearing :visual acuity≥0.3, 3 cases; visual acuity≥0.05, 6 cases. Conclusions Prevention can prevent the genesis of blindness. The students of residual visual acuity should wear visual aids.